解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Understanding the mechanisms governing the type of induced immune response after microbial invasion, could be of crucial importance for the rational design of a bacteria-based vaccine. Targeting a vaccine directly to dendritic cells (DCs), which are considered the most powerful antigen presenting cells, could be extre...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00094
更新日期:2001-12-01 00:00:00
abstract::Gammaherpesviruses (gammaHV) establish a life-long latency in the host and are associated with a number of malignant human diseases. It is generally believed that T cells play a major role in controlling the initial acute infection and subsequently maintaining the virus in a quiescent state. However, the nature of the...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1078/0171-2985-00104
更新日期:2001-12-01 00:00:00
abstract::Autoantibodies against DNA topoisomerase I (anti-topo I) have been reported to be specific to systemic sclerosis (SSc), however, anti-topo I was detected in patients with silicone breast implants, SLE without features of SSc, and rheumatic diseases. We detected anti-topo I positive silicosis patients without any sympt...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00055
更新日期:2001-12-01 00:00:00
abstract::CD147 is a broadly expressed cell surface molecule of the immunoglobulin superfamily whose expression is up-regulated upon T cell activation. Engagement of CD147 by CD147 monoclonal antibodies (mAbs) has been shown to induce homotypic aggregation of U937 cells. To study intracellular signal transduction induced by the...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(01)80015-2
更新日期:2001-05-01 00:00:00
abstract::Cytotoxicity and production of cytokines are two important functions of NK cells. These two different NK functions were studied in a syngeneic rat model in relation to MHC class I expression. We focussed on the mechanism by which NK cells modulate MHC class I expression on target cells and how this interferes with NK ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(00)80037-6
更新日期:2000-11-01 00:00:00
abstract::In mice, monoclonal antibody (mAb) to the alpha1 integrin abrogate gastro-intestinal damage during graft-versus-host-disease (GVHD), suggesting anti alpha1 mAb as candidates for treatment in humans as well. Our current data show that one such reagent, mAb 1B3.1, when immobilized to plastic wells via rabbit- anti murin...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(00)80031-5
更新日期:2000-09-01 00:00:00
abstract::In a subgroup of CVID T cell abnormalities have been reported. Peripheral blood T lymphocytes from patients with common variable immunodeficiency (CVID) and blood donors were examined for expression of CD8alpha, CD8beta and CD28. In CVID, three CD8+ T cells could be defined: CD8beta(high)CD28+ (expressing CD8beta at a...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(00)80062-5
更新日期:2000-08-01 00:00:00
abstract::Blood dendritic cell precursors (DCps) are identified as mononuclear leukocytes expressing HLA-DR but lacking the characteristic antigens associated with T cells (CD3), NK cells (CD16 and CD56) and B cells (CD 19). Dendritic cell precursors are distinguished from monocytes by their lack of expression of CD64 rather th...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(00)80053-4
更新日期:2000-05-01 00:00:00
abstract::The role of the thymic microenvironment in the development of murine thymic B cells has yet to be fully clarified. We therefore investigate the microenvironment that supports the development of mature thymic B cells (sIg+/B220+/CD43-B cells) from thymic B cell progenitors with immunophenotypes of sIg-/B220med/CD43+ ce...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(00)80071-6
更新日期:2000-04-01 00:00:00
abstract::CD8-positive cytotoxic T cells (CTL) recognize antigenic peptides in combination with major histocompatibility complex (MHC) class I molecules on the surface of syngeneic antigen presenting cells (APC). In the present paper we show that cells from tumor antigen-specific CTL clones present their cognate antigenic pepti...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(00)80088-1
更新日期:2000-01-01 00:00:00
abstract:UNLABELLED:The lymphoid tissue of the appendix is considered as part of the gut-associated lymphoid tissue (GALT). In order to understand better the immunological significance of the appendix we analyzed the cellular composition of normal and inflamed human appendix tissue by flow cytometer with special attention to ex...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(00)80098-4
更新日期:2000-01-01 00:00:00
abstract::Toxoplasma gondii is a widespread protozoan parasite that causes severe disease only in immunocompromised individuals. Equipped with excellent animal models and relatively advanced systems for genetics, T. gondii provides an excellent system for understanding pathogenesis. Resistance to toxoplasmosis is governed by ra...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(99)80061-8
更新日期:1999-12-01 00:00:00
abstract::The humoral immune response against alpha(1-->3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice for...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(99)80046-1
更新日期:1999-09-01 00:00:00
abstract::Immunosuppressive effects of corticosteroids are generally known, but the mechanisms influencing the immune system are poorly understood. However, a correlation between cortisol levels and cytokine production has been reported by several investigators. In the present study we determined cortisol concentrations in huma...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(99)80072-2
更新日期:1999-06-01 00:00:00
abstract::Bone marrow-derived macrophages (BMM) comprise a population of quiescent cells which can be activated by defined signals. Here, we directly compare the release of chemokines and monokines by BMM raised either in serum-supplemented or in serum-free medium in response to Listeria monocytogenes EGD or Mycobacterium bovis...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(99)80037-0
更新日期:1999-02-01 00:00:00
abstract::People deficient in C1-INH present recurrent angioedema localized to subcutaneous or mucous tissues. The defect can be caused by impaired synthesis, due to a genetic defect (hereditary angioedema), or by increased catabolism (acquired angioedema). In our experience the majority of patients with acquired angioedema (16...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(98)80041-7
更新日期:1998-08-01 00:00:00
abstract::A C1q receptor that upregulates the phagocytic capacity of professional phagocytes, C1qRp, has been identified, and its primary structure determined by cDNA cloning and sequencing. Monoclonal antibodies that immunoprecipitate this 126,000 Mr polypeptide inhibit the enhancement of phagocytosis triggered not only by C1q...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(98)80031-4
更新日期:1998-08-01 00:00:00
abstract::The major target organ of systemic infection with the intracellular bacterium Listeria monocytogenes is the liver, to where inflammatory leukocytes are rapidly recruited. We determined by reverse transcriptase polymerase chain reaction the early chemokine response in the liver after systemic infection of mice with lis...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(98)80066-1
更新日期:1998-07-01 00:00:00
abstract::Interleukin-7 (IL-7) supports the proliferation of mature T lymphocytes, however, the cellular source of IL-7 for T lymphocyte activation has not been well established. We therefore investigated whether human peripheral blood dendritic cells (DC) produce IL-7 as a contribution towards T lymphocyte activation. Human CM...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(98)80075-2
更新日期:1998-03-01 00:00:00
abstract::Based on the similar effects that HIV-1 gp41 like human type I interferons (IFN-alpha and -beta) upregulated MHC expression and inhibited lymphocyte proliferation, we compared amino acid sequences of gp41 and human type I interferons (IFN-alpha and -beta), and found sequence-similarity existing between the immunosuppr...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(98)80043-0
更新日期:1998-02-01 00:00:00
abstract::We have examined the role of CD26 (dipeptidyl peptidase IV) in the adhesion of resting and activated T lymphocytes to endothelial cells and fibroblasts. For this purpose, we ran a short-time adhesion assay under different strategies: Adhesion of T lymphocytes was determined in the presence of different anti-CD26 monoc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(98)80053-3
更新日期:1998-02-01 00:00:00
abstract::When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS. Tolerant cells still express the CD14 receptor and they can still be activated to mobilize NF-kappa B into nucleus. Ana...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(97)80029-0
更新日期:1997-12-01 00:00:00
abstract::The Early Growth Response Genes (EGR-1 to AT133/EGR-4) encode a family of proteins that are composed of three homologous consecutive zinc fingers of the Cys2-His2 type and different flanking sequence. Upon growth stimulation of resting cells the four EGR-genes are simultaneously transcribed. We have analyzed the expre...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(97)80039-3
更新日期:1997-12-01 00:00:00
abstract::Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis. The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorl...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(97)80049-6
更新日期:1997-12-01 00:00:00
abstract::We investigated the mRNA expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in human T cell lymphotropic virus type I (HTLV-I) p40tax-transfected U937 cells, a human monoblast cell line. Transfection of HTLV-I p40tax U937 cells induced up-regulation of iNOS mRNA expression and...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(97)80083-6
更新日期:1997-11-01 00:00:00
abstract::In this study the SEB-activated LAK cytotoxicity was identified and characterized in human peripheral blood lymphocytes (PBMC). After 3 days of SEB stimulation, the PBMC acquired a cytotoxicity against traditional LAK targets, K-562 and Daudi, beside that human glomerular endothelial cells (HGEC) were effectively lyse...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(97)80056-3
更新日期:1997-06-01 00:00:00
abstract::We studied local events in the popliteal lymph nodes of CD4-deficient mice following foot pad injection with an MMTV strain which carries the gene for a V beta 14-specific superantigen. Injection of the V beta 14-specific MMTV induced vigorous expansion of V beta 14+ CD4+ T cells and B cells in their lymph nodes of CD...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(96)80053-2
更新日期:1996-08-01 00:00:00
abstract::A cyclophosphamide (CP)-induced tolerance system in mice that primarily consists of donor cell injection followed by CP-treatment was found useful for inducing a long-lasting allo- or xeno-tolerance to various solid organs. In the cells-followed-by-CP system, the sequential mechanisms of tolerance were clarified using...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(96)80033-7
更新日期:1996-07-01 00:00:00
abstract::In order to evaluate the role of CD8+ T cells in cutaneous leishmaniasis, major histocompatibility complex (MHC) class II-deficient mice of C57BL/6 background lacking functional CD4+ T cells were infected with Leishmania major. In contrast to C57BL/6 wild-type mice which are resistant to infection with L. major, these...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(96)80043-X
更新日期:1996-07-01 00:00:00
abstract::Porphyromonas gingivalis 381 lipid A induced strong mitogenic response in splenic B cells separated from LPS-non-responsive C3H/HeJ mice as well as LPS-responsive C3H/HeN mice, by using a magnetic cell sorting system. The lipid A also exhibited mitogenic activity in splenic T cells. P. gingivalis lipid A induced lower...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(96)80062-3
更新日期:1996-01-01 00:00:00
abstract::A sero-epidemiologic correlation study on immune parameters which would correlate with the frequency of common colds (FCC) had been conducted in 1992. There, an inverse relationship between circulating adhesion molecules CD54 and CD58 and FCC was found. Eighteen months later we performed an analogous assessment in ord...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(96)80005-2
更新日期:1996-01-01 00:00:00
abstract::It is well known that adherence of monocytes (MO) to extracellular matrix substrates or tissue culture plastic activates these cells and induces the expression of a multitude of genes. Especially, it was described, that MO are primed by cell adhesion to produce higher amounts of some cytokines, e.g. interleukin (IL)-8...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(97)80069-1
更新日期:1996-01-01 00:00:00
abstract::Human cell lines of myelo/monocytic origin express the cellular receptor for urokinase-type plasminogen activator (uPA-R). The receptor localizes urokinase-type plasminogen activator (uPA) to the surface of the cell, where it can convert plasminogen to the active serine proteinase plasmin. Plasmin may subsequently acc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80104-x
更新日期:1995-11-01 00:00:00
abstract::During bacterial peritonitis of patients on continuous ambulatory peritoneal dialysis (CAPD) leukocytes, particularly polymorphonuclear neutrophilic granulocytes (PMNs), migrate into the peritoneal cavity. However, at the site of inflammation PMNs are not sufficiently able to protect the host against micro-organisms. ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80430-4
更新日期:1995-08-01 00:00:00
abstract::The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demo...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(11)80540-1
更新日期:1995-07-01 00:00:00
abstract::Human Lymphocyte Associated Antigen-1 (LFA-1, CD11a/CD18, alpha L/beta 2) and p150,95 (CD11c/CD18, alpha X/beta 2) are cell surface alpha/beta heterodimers that, together with Mac-1 (CD11b/CD18, alpha M/beta 2) comprise the leukocyte-restricted beta 2 subfamily of integrins. LFA-1 is the only integrin expressed on all...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80560-7
更新日期:1995-07-01 00:00:00
abstract::The homotypic cell aggregation of leukocytes is an unique adhesive event which is caused by cellular activation. Anti-CD44 monoclonal antibody (mAb) induces homotypic cell aggregation of hematopoietic cell lines expressing CD44, but the mechanism of homotypic cell aggregation is poorly understood. We used four mAbs ag...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80152-X
更新日期:1995-06-01 00:00:00
abstract::CD45RA monoclonal antibodies recognize the higher molecular weight isoforms (220 and 205 kDa) of leukocyte common antigen family (CD45), which are typically expressed on B cells and unstimulated T cells. We have found that there are at least three distinct CD45RA monoclonal antibodies which react with platelet 42 kDa ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80103-8
更新日期:1995-02-01 00:00:00
abstract::Intraepithelial intestinal T lymphocytes (IEL) bearing alpha beta or gamma delta T cell receptors (TCR) are positioned to serve as a first line of defense against enteric pathogens. To investigate whether intestinal IEL are subject to antigenic selective forces distinct from that influencing (xp T cells in the periphe...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80409-2
更新日期:1994-12-01 00:00:00
abstract::Phagocytosis Inhibitory Factor (PIF), a small (< 3000 D) molecule, was partially purified from human red blood cell membranes. This factor inhibits latex phagocytosis by monocytic cells. PIF is not toxic under the experimental conditions employed and the phagocytosis inhibitory activity is reversible since removal of ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80410-9
更新日期:1994-12-01 00:00:00